Let's lake this one step at a time.

做这事我们要一步一步来。

Run it by me again, if you don't mind.

不介意的话，请再说一遍。

An economic recession now seems more than likely.

现在看来，经济衰退的可能性相当大。

Winning isn't everything.

赢并不是一切。

Take heart, we'll find a way out.

振作起来，我们会有办法的。

I must take issue with your over what you said at the meeting.

我要和你好好谈谈你在会上说的那些话。（take issue with someone: 对某人的观点提出异议。）